Abstract:

Objective To evaluate the efficacy and safety of canaloplasty in treating adult patients with open angle glaucoma. Design Retrospective case series. Participants 41 cases (50 eyes) of adult patients with open-angle glaucoma treated in Beijing Tongren Eye Center from January 2011 to April 2014. Method All patients were conducted with canaloplasty. The patients were followed up at 3, 6 months, 1 year, 1.5 years, and 2 years after the surgery. The intraocular pressure(IOP) and the use of IOP lowering drugs were comparative observed in youth group and middle-old age group, non-high myopia group and high myopia group. The complete success was defined as IOP was lower than 21 mmHg without any IOP lowering drugs, and conditional success was defined as IOP was lower than 21 mmHg with IOP lowering drugs. Main Outcome Measures  IOP and usage status of IOP lowering drugs. Results Before the surgery, the average IOP was (24.9 ±8.1) mmHg, the average drug usage was (2.7±1.2) kinds of drugs. The mean IOP at 3, 6 months, 1 year, 1.5 years and 2 years after the surgery were (15.1±3.0) mmHg, (15.5±3.5) mmHg, (15.4±3.1) mmHg, (15.6±4.2) mmHg, (15.8±4.9) mmHg, respectively, all of which were significantly lower than those before surgery (all P=0.000). At 2 years after surgery, the average drug usage was (0.8±1.4) kinds of drugs, which was significantly less than that before surgery (P=0.000). At 2 years after surgery, the complete success rate was 70.3%, and the conditional success rate was 92.6%. There was no significant different between the youth group and middle-old age group in IOP and IOP lowering drugs at different time point after operation. One year after surgery, IOP of high myopia group (14.4±3.3 mmHg) was lower than non-high myopia group (16.2±4.5 mmHg) (P=0.035). There was no significant different between two groups in IOP and IOP lowering drugs during follow-up.  Conclusion  Two years follow-up showed that canaloplasty is an effective and safe way to reduce IOP in adults with open angle glaucoma. (Ophthalmol CHN, 2018, 27: 16-20)

Key words: canaloplasty, open angle glaucoma